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Tranexamic Acid is a synthetic derivative of the amino acid lysine, widely recognized for its antifibrinolytic properties.
Tranexamic Acid is a synthetic derivative of the amino acid lysine, widely recognized for its antifibrinolytic properties. It functions by inhibiting the activation of plasminogen to plasmin, a molecule responsible for the breakdown of fibrin clots. This mechanism makes Tranexamic Acid particularly effective in reducing or preventing excessive bleeding in various medical conditions.
In the realm of dermatology, Tranexamic Acid has gained attention for its potential in treating melasma and other hyperpigmentation disorders. Its ability to interfere with the interaction between melanocytes and keratinocytes helps in reducing melanin synthesis, thereby lightening hyperpigmented areas. This makes it a valuable component in topical formulations aimed at improving skin tone and texture.
Tranexamic Acid is also utilized in oral and injectable forms to manage heavy menstrual bleeding, trauma-induced hemorrhage, and during surgical procedures to minimize blood loss. Its versatility and efficacy in controlling bleeding have made it a staple in both acute and chronic treatment settings. Additionally, its safety profile is well-documented, with most adverse effects being mild and transient.
For prescribers, understanding the pharmacokinetics of Tranexamic Acid is crucial. It is rapidly absorbed when administered orally, with peak plasma concentrations reached within a few hours. The drug is primarily excreted unchanged in the urine, necessitating dose adjustments in patients with renal impairment. This pharmacological insight aids in optimizing therapeutic outcomes while minimizing potential risks.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
It is an antifibrinolytic. It slows the breakdown of blood clots, which reduces bleeding. Oral tablets are FDA-approved for cyclic heavy menstrual bleeding, and the injection is approved as well.
In the skin the reasoning is different and has nothing to do with clotting: by reducing plasmin activity in skin cells, tranexamic acid is thought to lower the signals that prompt pigment production. That mechanism is plausible but not settled.
Anyone with active clotting or thromboembolic disease, a history of or intrinsic risk of thrombosis including retinal vein or artery occlusion, a past subarachnoid hemorrhage, or an allergy to it.
Combination hormonal contraception, the pill, patch, or ring, is a contraindication in the FDA label, because the combination further raises clot risk. Many people treated for melasma or heavy periods are on it, so tell your prescriber. Kidney disease requires a lower dose.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
