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Amitriptyline HCl 5%/Cyclobenzaprine HCl 2%/Gabapentin 4%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel

Bayview Pharmacy compounds a customized Amitriptyline, Cyclobenzaprine, Gabapentin, Ketoprofen, and Lidocaine topical gel to help manage neuropathic pain, fibromyalgia, and osteoarthritis.
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Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Cyclobenzaprine Hydrochloride
Gabapentin
Ketoprofen
Lidocaine Hydrochloride
Topical Gel
65307e242957e0fa0a0d5890

Formula Information

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This formulation is a compounded topical gel containing Amitriptyline HCl 5%, Cyclobenzaprine HCl 2%, Gabapentin 4%, Ketoprofen 10%, and Lidocaine HCl 5%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Amitriptyline HCl is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It can help to relieve chronic pain, particularly neuropathic pain. Cyclobenzaprine HCl is a muscle relaxant that can help to relieve muscle spasms and associated pain. Gabapentin is an anticonvulsant that is also used for its analgesic properties, particularly in treating neuropathic pain. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can help to reduce inflammation and pain. Lidocaine HCl is a local anesthetic that can provide immediate relief from pain by numbing the affected area.

This formulation can be used to treat a variety of disease states that involve chronic pain, inflammation, muscle spasms, and neuropathic pain. These may include conditions such as fibromyalgia, post-herpetic neuralgia, diabetic neuropathy, osteoarthritis, and other musculoskeletal conditions. The combination of active ingredients in this formulation works synergistically to provide comprehensive pain relief and improve the quality of life for patients suffering from these conditions.

It is important for patients to use this medication as directed by their healthcare provider. The medication should be applied to the affected area as directed, and patients should wash their hands immediately after application. Patients should also avoid contact with the eyes, nose, mouth, and other mucous membranes. If any adverse reactions occur, such as skin irritation or allergic reactions, patients should discontinue use and contact their healthcare provider immediately.

For prescribers, it is important to consider the individual patient's condition, medical history, and other medications when prescribing this formulation. The potential for drug interactions and the patient's tolerance to the individual components of the formulation should be considered. Regular follow-up with the patient is also important to monitor the effectiveness of the treatment and make any necessary adjustments.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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This topical gel formulation contains a combination of Amitriptyline HCl, Cyclobenzaprine HCl, Gabapentin, Ketoprofen, and Lidocaine HCl. These active ingredients work synergistically to manage pain and inflammation associated with various conditions such as neuropathic pain, fibromyalgia, and musculoskeletal disorders. However, it's important to be aware of potential drug interactions that may occur with this formulation.

Amitriptyline HCl, a tricyclic antidepressant, may interact with other antidepressants, antipsychotics, and certain heart medications. It can increase the risk of serotonin syndrome when combined with other serotonergic drugs. It may also enhance the effects of other CNS depressants, including alcohol.

Cyclobenzaprine HCl, a muscle relaxant, may interact with monoamine oxidase inhibitors (MAOIs), increasing the risk of serious side effects. It can also enhance the effects of other CNS depressants, including alcohol, benzodiazepines, opioids, and antihistamines.

Gabapentin, an anticonvulsant, may interact with antacids, reducing its absorption and effectiveness. It may also enhance the effects of other CNS depressants, including opioids, antihistamines, and alcohol.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with blood thinners, increasing the risk of bleeding. It may also interact with other NSAIDs, corticosteroids, and certain blood pressure medications, increasing the risk of kidney damage and heart problems.

Lidocaine HCl, a local anesthetic, may interact with other local anesthetics and certain heart medications, potentially leading to serious heart problems.

It's important to inform your healthcare provider of all medications, supplements, and herbal products you are currently taking before starting this topical gel. This includes over-the-counter medications and recreational substances such as alcohol. Also, inform your healthcare provider if you have any existing health conditions, as these may affect how this medication works or increase the risk of side effects.

Remember, this medication is for topical use only and should not be ingested or applied to broken skin or mucous membranes. Always use this medication as directed by your healthcare provider. If you experience any unusual symptoms or side effects, contact your healthcare provider immediately.

If you have any questions or concerns about this medication, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

How Does it Work

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This topical gel formulation combines five active ingredients: Amitriptyline HCl, Cyclobenzaprine HCl, Gabapentin, Ketoprofen, and Lidocaine HCl. Each of these ingredients plays a unique role in managing pain and inflammation.

Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce pain sensation. In a topical formulation, it can provide localized relief from neuropathic pain.

Cyclobenzaprine HCl is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain, thereby reducing muscle spasms and providing relief from associated pain and discomfort.

Gabapentin is an anticonvulsant and nerve pain medication. It is believed to work by affecting the way the body senses pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Lidocaine HCl is a local anesthetic. It works by blocking nerve signals in your body and is often used to relieve pain and discomfort from skin irritations and minor cuts.

When combined in a topical gel, these ingredients work together to provide comprehensive pain relief. The gel is designed to be easily applied to the skin, allowing for targeted treatment. The active ingredients are absorbed through the skin, providing localized relief from pain and inflammation. This can be particularly beneficial for patients who cannot tolerate oral medications or for those who require targeted pain relief.

This formulation can be used to treat a variety of disease states, including neuropathic pain, muscle spasms, arthritis, and other conditions associated with inflammation and pain. As with any medication, it is important to use this formulation under the guidance of a healthcare provider.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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Outside of its known applications, the compound formulation of Amitriptyline HCl 5%/Cyclobenzaprine HCl 2%/Gabapentin 4%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel may have several alternative uses. This topically applied gel could potentially provide relief from different other conditions, providing the active ingredients are suitable for the patient’s medical profile.

This formulation, primarily used to manage disorders relating to muscles, nerves, and connective tissues, might also be beneficial as an adjunct therapy in disorders causing inflammation and acute conditions, such as sprains, strains, and bursitis.

Additionally, since Gabapentin is known to treat epileptic seizures, this compounded might serve as an alternative treatment to manage specific neurological conditions. However, this off-label use would require further scientific investigation. Importantly, Cyclobenzaprine and Amitriptyline, often used for muscle relaxation, and as an anti-depression medication, respectively, may be beneficial for treating symptoms related to chronic pain disorders.

User safety remains paramount, however. This compound should be used as prescribed by a licensed professional, and any variations to this effect should only be considered after a detailed consultation with the healthcare provider. Skin sensitivity or allergy related to any of the ingredients is also a primary concern. Cases of unusual skin reactions, intense burning, blisters, or redness should be followed with immediate consultation with a pharmacist or healthcare provider.

This formulation is not intended for internal use or application to open wounds or damaged skin. Moreover, this product is not ideal for ocular, aural, or oral use due to the risk of discomfort or injury. If accidental exposure occurs, affected individuals should immediately flush the area with water and seek medical help.

Please reach out to your healthcare provider or our team at Bayview Pharmacy if you have any questions or need further clarification on the use of this product.

Frequently Asked Questions

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What is this compounded formulation made of?

This formulation is a combination of Amitriptyline HCl 5%, Cyclobenzaprine HCl 2%, Gabapentin 4%, Ketoprofen 10%, and Lidocaine HCl 5%.

What form does this formulation take?

This compounded formulation is a semisolid substance, similar to a gel. It is dispensed from a pump mechanism for targeted treatment or skin application.

How should I apply this formulation?

The formulation should be applied directly to the area of discomfort using the pump to dispense the amount desired. As it's a targeted treatment, apply it only to the area needing relief.

When do I need to use this medication?

You should use this medication as prescribed by your healthcare provider. Always follow the instructions given by your physician or the pharmacist.

The effectiveness of this formulation comes from its compound mix of medications. These specific percentages of active ingredients have been carefully chosen to provide maximum relief for various symptoms.

Can this medication be used for all skin types?

Generally speaking, this medication can be used on all skin types, however, if you have sensitive skin or known allergies, you should consult with your healthcare provider before using this medication.

What precautions should I take while using this formulation?

Always use this medication as advised by your healthcare provider. Avoid contact with eyes and mouth, and do not apply on open wounds or burns. Consult with your doctor if your condition worsens or does not improve after several days.

Are there any side effects to this topical gel?

Side effects can vary based on individual reactions to medications. Some potential side effects include skin irritation or redness at the site of application. If severe or persistent side effects occur, contact your healthcare provider immediately.

Can other medications interfere with this compounded formulation?

Certain medications may interact with this formulation. Always inform your healthcare provider about any other medications, supplements, or herbal products you are currently using.

How should I store this compounded formulation?

This formulation should be stored at room temperature, away from heat and direct light. Keep the container tightly closed when not in use. Do not freeze the medication.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Related Formulas

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NY, NJ, NH, FL, and ME. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCl 5%/Cyclobenzaprine HCl 2%/Gabapentin 4%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel
Topical Gel
60 g
controlled

Apply topically to affected area(s)