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Midodrine Hydrochloride is a potent vasopressor and antihypotensive agent primarily used to treat orthostatic hypotension.
Midodrine Hydrochloride is a potent vasopressor and antihypotensive agent primarily used in the management of orthostatic hypotension. It functions as a prodrug, metabolizing into its active form, desglymidodrine, which acts as an alpha-1 adrenergic receptor agonist. This action results in increased vascular tone and blood pressure, making it an effective treatment for patients experiencing symptoms of low blood pressure upon standing.
Clinically, Midodrine Hydrochloride is valued for its ability to improve blood flow and reduce symptoms such as dizziness and lightheadedness, which are common in conditions like dysautonomia and neurogenic orthostatic hypotension. Its pharmacokinetic profile is characterized by rapid absorption and conversion to its active metabolite, with peak plasma concentrations typically reached within an hour of oral administration.
Prescribers should be aware of the potential side effects associated with Midodrine Hydrochloride, which may include piloerection, pruritus, and urinary retention. It is crucial to monitor patients for supine hypertension, a known risk due to the drug's mechanism of action. Adjustments in dosing or administration timing may be necessary to mitigate this risk.
Midodrine Hydrochloride is contraindicated in patients with severe organic heart disease, acute renal disease, and urinary retention. It is also not recommended for use in patients with persistent and excessive supine hypertension. Careful patient selection and monitoring are essential to ensure the safe and effective use of this medication in clinical practice.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
We do not have a patient page for this ingredient yet. That does not mean we cannot make it. Bayview compounds this ingredient to a prescriber's order, and our full compounding formulary lists every preparation we make. Viewing the formulary requires a prescriber account.
Prescriber sign inA sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
